Panthenol (Vitamin B5) in Skincare: What It Does

I by no means knew what panthenol in skincare means or what it does earlier than working in magnificence. It sounded extra like a preservative or one thing unfriendly, however is panthenol dangerous for pores and skin? Upfront, no. Actually, panthenol is likely one of the finest humectants that works by pulling water from the surroundings on to your pores and skin layers, growing hydration and plumping. Ok, it does far more than that, however let’s begin with the start.

What is panthenol?

Panthenol is a compound comprised of pantothenic acid, an important nutrient present in each dwelling cell that the physique wants. Once utilized to the pores and skin, panthenol converts into vitamin B5, enjoying a number of roles. Vitamin B5 in skincare can bind and maintain water successfully, growing moisture within the pores and skin and preserving it comfortable, elastic, and agency.[1] The particular factor about panthenol is that it acts as a humectant and emollient on the identical time. While humectants appeal to and bind water to the tissue, emollients soften and seal the cracks, stopping water evaporation.

Panthenol in skincare will be present in concentrations from 1 to five%. A examine that ran for 30 days evaluated the results on transepidermal water loss (TEWL) and moisture after washing the pores and skin with SLSs (foaming drying detergent) with panthenol formulations from 1% to five%. The outcomes astounded us! Just 1% panthenol diminished TEWL, elevated pores and skin hydration, and maintained pores and skin integrity.[2]

Panthenol’s advantages for pores and skin

Panthenol’s advantages for pores and skin embrace hydration and moisture enhance, and resulting from its calming and delicate profile, it aids in easing inflammations and lowering redness too. Here’s how panthenol can enhance your pores and skin:

Deeply hydrates: As a water-soluble humectant, panthenol penetrates the pores and skin, pulling up from the surroundings, quenching the tissue, and growing moisture retention.

Hinders TEWL: By boosting moisture, panthenol reinforces the protecting barrier, which helps stop water evaporation. 

Speeds up wound therapeutic: Since panthenol strengthens the barrier, it has a key position in encouraging wound therapeutic, particularly if utilized as quickly because the harm has been finished.[3] Also, panthenol has a task in encouraging keratinocytes — which make up 90% of epidermal cells — proliferation.[4]

Calms and relieves irritation: Panthenol is listed as an anti-inflammatory agent, nice for alleviating redness brought on by UV publicity, calming infected pimples, and lowering itchiness.[1]

Panthenol can have totally different names in your skincare product label. Look for provitamin B5, butanamide, and d-pantothenyl alcohol.

Panthenol unwanted side effects

As a gentle, calming ingredient, panthenol is tolerated by all pores and skin varieties, delicate ones included. Still, it’s at all times good to do a patch take a look at once you add a brand new product into your routine. 

How to make use of it

As a flexible compound, panthenol will be paired with most skincare actives, together with the much less delicate ones, resembling retinol, AHAs, and BHAs. You’ll discover panthenol in numerous merchandise, so it ought to at all times be utilized as suggested by the product at hand. 

Best panthenol merchandise:

  1. The Ordinary Hyaluronic Acid 2% + B5, view on The Ordinary
  2. Cosrx B5 D-Panthenol Ampoule, view on Amazon
  3. Purito B5 Panthenol Re-barrier Cream, view on Amazon
  4. Medik8 Hydr8 B, view on Dermstore
  5. Allies Of Skin Molecular Barrier Recovery Cream Balm, view on Allies of Skin


  1. National Library of Medicine National Center for Biotechnology Information, Panthenol
  2. Camargo FB Jr, Gaspar LR, Maia Campos PM. Skin moisturizing results of panthenol-based formulations. J Cosmet Sci. 2011 Jul-Aug;62(4):361-70. PMID: 21982351.
  3. Gorski, Julian et al. “Dexpanthenol in Wound Healing after Medical and Cosmetic Interventions (Postprocedure Wound Healing).” Pharmaceuticals (Basel, Switzerland) vol. 13,7 138. 29 Jun. 2020, doi:10.3390/ph13070138
  4. Daisaku Kobayashi, Miho Kusama, Masaaki Onda, Norimichi Nakahata, The Effect of Pantothenic Acid Deficiency on Keratinocyte Proliferation and the Synthesis of Keratinocyte Growth Factor and Collagen in Fibroblasts, Journal of Pharmacological Sciences, Volume 115, Issue 2, 2011, Pages 230-234, ISSN 1347-8613,

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